Individuals with Down syndrome who survive into adulthood face the additional challenge of early-onset dementia, in which toxic amyloid plaques build up in the brain. The condition is strikingly ...

1Xtra's A.Dot already thinks Stormzy's debut album GSAP is going to be the best album of 2017. "Anticipation is the word that sums this all up," the 1Xtra Breakfast host tells Newsbeat. Stormzy teased ...

2016 came and went without what would be Stormzy's debut album despite early word that it was set to release late in the year, but don't fret - the time seems to be arriving sooner rather than later.

Several cleavage reactions are catalysed by the presenilin complex (Fig. 1). Cleavage of substrates at residues 48 and 49 — termed ɛ-cleavage — generates soluble intracellular-domain fragments that ...

To purify the potential target protein, we synthesized a biotinylated derivative of imatinib, ‘biotin-imatinib’ (Supplementary Methods and Supplementary Fig. 3). Solubilized γ-secretase components, ...