IgG4-related disease has been described in virtually every organ system: the biliary tree, salivary glands, periorbital tissues, kidneys, lungs, lymph nodes, meninges ...

The discovery of systemic disease related to raised tissue and serum immunoglobulin G4 (IgG4) is changing diagnostic and therapeutic practice in many medical specialties. Orbital inflammation remains ...

WASHINGTON -- Patients with IgG4-related disease appeared to benefit from inebilizumab (Uplizna), currently approved for neuromyelitis optica (NMO), in a pivotal clinical trial. Just 10% of patients ...

SAN DIEGO — Rituximab (Rituxan, Genentech) is a potential treatment option in the multiorgan fibroinflammatory disorder known as immunoglobulin G4-related disease (IgG4), according to researchers ...

Subtype 1 is an IgG4-associated systemic disorder with pancreatic involvement; it is more common in men, especially older men. [14] The symptoms are nonspecific and include mild epigastric abdominal ...

The FDA’s approval of inebilizumab has heralded a new era for patients with IgG4-related disease, while novel agents moving ...

IgG4-related disease is an autoimmune disorder affecting millions and has no established cure. Previous research indicates that T cells, a major component of the immune system, and the immunoglobulin ...

IgG4-related sclerosing disease is an immune-mediated disease that affects multiple organs at the same time in some people. This can often include an inflamed pancreas, organ swelling, disease in the ...

Amgen has bagged a second indication for its B cell-depleting therapy Uplizna after the FDA cleared it for rare inflammatory disease IgG4-related disease (IgG4-RD). Acquired as part of its $27.8 ...

In a recent study posted to bioRxiv* preprint server, researchers in Germany assessed the differences in antigen-specific immunoglobulin G (IgG) subtypes between post-COVID syndrome (PCS) patients and ...

Autoimmune diseases are a medical conundrum. In people with these conditions, the immune system of the body, the designated defense system, starts attacking the cells or organs of its own body, ...