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1979 hit film ranked among 'best movies of all time'

'Life of Brian' was given a 96% score on Rotten Tomatoes, and is known as one of the greatest movies of all time.

10 things to know about the Blue Angels ahead of Florida show

The Blue Angels headline the Cocoa Beach Air Dot Show this weekend. Here are 10 things to know before watching from the beach ...

What locals know about Torquay that tourists miss on Devon's English Riviera

Sadly the hotel that inspired John Cleese, when he visited with the Monty Python team in 1973, is no more. The Gleneagles was ...

The 21 Yorkshire places you didn't know were in Hollywood blockbusters

Yorkshire locations highlighted in the guide include: Castle Howard (Bridgerton); North York Moors Railway (Harry Potter, ...

New open-source Python-based software boosts space-weather modeling

University of Birmingham experts have created open-source computer software that helps scientists understand how fast-moving ...
eLife

Molidustat Targets a Synthetic Lethal Vulnerability in APC-Mutant Colorectal Cancer through GSTP1 and PHD2 Co-Inhibition

This important paper substantially advances our understanding of how Molidustat may work, beyond its canonical role, by identifying its therapeutic targets in cancer. This study presents a compelling ...
AHA/ASA Journals

Targeting Interleukin-8–Mediated Cellular Crosstalk Reverses Hypertrophic Cardiomyopathy and Cardiac Fibrosis in Noonan Syndrome

BACKGROUND: Genetic variants in components or regulators of the RAS-MAPK signaling pathway are causative for severe and early-onset hypertrophic cardiomyopathy (HCM) in patients with Noonan syndrome ...